About NanoFUSE Biologics
NanoFUSE Biologics develops FDA-cleared synthetic 45S5 bioactive glass osteobiologic technology designed to support bone regeneration and healing.
Founded in 2018, NanoFUSE Biologics was established to harness the regenerative potential of bioactive glass and advance its application in modern osteobiologic solutions. Bioactive glass has been clinically studied and utilized for more than three decades, forming the foundation of a shift from passive implants to regenerative biomaterials..
Our Technology
NanoFUSE® is a proprietary and patented synthetic bioactive ceramic–based 45S5 bioactive glass osteobiologic. It is the only commercially available synthetic osteobiologic designed to combine two active regenerative components in a single product:
Synthetic 45S5 bioactive glass
Demineralized bone matrix (DBM)
This unique integration supports regenerative bone formation, fusion, and healing when placed in bony voids or gaps.
How NanoFUSE Works
When mixed with an aqueous body fluid such as blood, NanoFUSE initiates a controlled ionic exchange, releasing calcium, sodium, silica, and phosphate ions. This process creates a local biological environment favorable to cellular activity and mineralization.
As the reaction progresses, a three-dimensional ultra-porous calcium hydroxyapatite (HA) layer forms. This HA scaffold supports osteoblast attachment and new bone formation, facilitating remodeling toward native bone.
A Tri-Modal Regenerative Mechanism
NanoFUSE Biologics’ performance is driven by three complementary mechanisms:
Osteoinductivity — via the DBM component
Osteopromotivity — through bioactive ion release
Osteoconductivity — from the bioactive glass–derived HA scaffold
Together, these mechanisms support bone regeneration, fusion, and healing across approved clinical applications.
Advantages
FDA-cleared since 2012
Expanded spine indications cleared in 2015
Patented design and manufacturing process
Moldable and customizable handling
Flowable putty format available
Anti-microbial properties
5-year sterile packaged shelf life
Available in multiple forms
Proven clinical track record