NanoFUSE Biologics


NanoFUSE Biologics are clinically proven to fuse the spine. The synergistic blend of osteopromotive and anti-infective bioactive glass and osteoinductive DBM makes NanoFUSE clinically proven to be more effective than the competition and DBM alone


Nano - acdf with nanofuse 2 weeks post op.png

Bioactive Glass Research


Proven to Heal Bone

Bioactive glass can act as a vehicle for delivering ions beneficial for healing and has been shown to regulate cells and improve bone growth and differentiation. Calcium released from the glass will react with phosphate ions present in the body fluids and deposit a nanocrystalline HA on the glass surface that mimics naturally formed HA by the process in which is made, the size, and morphology of the crystals.



Proven to Resorb Naturally

The bioactive glass in NanoFUSE is degradable in body fluids. The bioactive glass is chemically soluble, dissolving at rates ranging from ~2 to 5 μm per week.



Proven to be Anti-Infective

There is a lot of literature on the anti-infective properties of bioactive glass. There are several studies that show successful reduction of infection at the implant site. Bioactive glass is the only
anti-infective synthetic bone grafting material.



Proven to be Angiogenic

Trace ions in NanoFUSE bioactive glass composition such as copper and zinc are known to stimulate angiogenesis. Bioactive glasses containing these trace elements have been shown to stimulate vascular growth in vivo which can aid in the bone healing process.




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  31. “Mechanical Behaviour of Bioactive Glass Granules and Morselized Cancellous Bone Allograft in Load Bearing Defects,” Hulsen, D., Geurts, J., Gestel, N. V., Rietbergen, B. V., & Arts, J., Journal of Biomechanics, (2016). 49(7), 1121-1127.

  32. “Nanoscale Bioactive Glass Activates Osteoclastic Differentiation of RAW 264.7 Cells,” Detsch, R., Rübner, M., Strissel, P. L., Mohn, D., Strasser, E., Stark, W. J., Boccaccini, A. R., Nanomedicine, 11(9) (2016) 1093-1105.

  33. “Phosphate Glass Fibre Scaffolds: Tailoring of the Properties and Enhancement of the Bioactivity Through Mesoporous Glass Particles,” G. Novajra, N. G. Boetti, J. Lousteau, S. Fiorilli, D. Milanese and C. Vitale-Brovarone, Materials Science and Engineering, C (2016) 570-580.

  34. “Three-Dimensional Polymer Coated 45S5-type Bioactive Glass Scaffolds Seeded With Human Mesenchymal Stem Cells Show Bone Formation in Vivo,” Westhauser, F., Weis, C., Prokscha, M., Bittrich, L. A., Li, W., Xiao, K., Moghaddam, A., J Mater Sci: Mater Med Journal of Materials Science: Materials in Medicine, 27(7) (2016) doi:10.1007/s10856-016-5732-3

  35. “Enhanced Osteoprogenitor Elongated Collagen Fiber Matrix Formation by Bioactive Glass Ionic Silicon Dependent on Sp7 (Osterix) Transcription,” Varanasi, V. G., Odatsu, T., Bishop, T., Chang, J., Owyoung, J., & Loomer, P. M., Journal of Biomedical Materials Research Part A J. Biomed. Mater. Res.(2016).

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  38. “Bioactive Borate Glass Promotes the Repair of Radius Segmental Bone Defects by Enhancing the Osteogenic Differentiation of BMSCs,” Zhang, J., Guan, J., Zhang, C., Wang, H., Huang, W., Guo, S., Wang, Y., Biomed. Mater. Biomedical Materials, 10(6), (2015) 065011.

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  47. “Characterization and Biocompatibility of a Fibrous Glassy Scaffold,” Gabbai-Armelin, P. R., Souza, M. T., Kido, H. W., Tim, C. R., Bossini, P. S., Fernandes, K. R., Renno, A. C. (2015). J Tissue Eng Regen Med Journal of Tissue Engineering and Regenerative Medicine.

  48. “Effect of a New Bioactive Fibrous Glassy Scaffold on Bone Repair,” Gabbai-Armelin, P. R., Souza, M. T., Kido, H. W., Tim, C. R., Bossini, P. S., Magri, A. M., Renno, A. C. (2015). J Mater Sci: Mater Med Journal of Materials Science: Materials in Medicine, 26(5).

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  50. “Electrophoretic Deposition of Mesoporous Bioactive Glass on Glass–Ceramic Foam Scaffolds for Bone Tissue Engineering,” Fiorilli, S., Baino, F., Cauda, V., Crepaldi, M., Vitale-Brovarone, C., Demarchi, D., & Onida, B. (2015) J Mater Sci: Mater Med Journal of Materials Science: Materials in Medicine, 26(1).

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  53. “Improved Dimensional Stability with Bioactive Glass Fibre Skeleton in Poly(lactide-co-glycolide) Porous Scaffolds for Tissue Engineering,” Haaparanta, A., Uppstu, P., Hannula, M., Ellä, V., Rosling, A., & Kellomäki, M. (2015). Materials Science and Engineering: C, 56, 457-466.

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  56. “A Review of the Effect of Various Ions on the Properties and the Clinical Applications of Novel Bioactive Glasses in Medicine and Dentistry,” Ali, S., Farooq, I., & Iqbal, K. (2014). The Saudi Dental Journal, 26(1), 1-5.

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  58. “Cotton-Wool-Like Bioactive Glasses for Bone Regeneration,” Poologasundarampillai, G., Wang, D., Li, S., Nakamura, J., Bradley, R., Lee, P., Jones, J. (2014). Acta Biomaterialia, 10(8), 3733-3746.

  59. “Effect of Implant Design and Bioactive Glass Coating on Biomechanical Properties of Fiber-Reinforced Composite Implants,” Ballo, A. M., Akca, E., Ozen, T., Moritz, N., Lassila, L., Vallittu, P., & Närhi, T. (2014). Eur J Oral Sci European Journal of Oral Sciences, 122(4), 303-309.

  60. “Evaluation of the Bone Regeneration Potential of Bioactive Glass in Implant Site Development Surgeries: A Systematic Review of the Literature,” Ioannou, A. L., Kotsakis, G. A., Kumar, T., Hinrichs, J. E., & Romanos, G. (2014). Clin Oral Invest Clinical Oral Investigations,19(2), 181-191.

  61. “Healing of Critical-size Segmental Defects in Rat Femora Using Strong Porous Bioactive Glass Scaffolds,” Bi, L., Zobell, B., Liu, X., Rahaman, M. N., & Bonewald, L. F. (2014). Materials Science and Engineering: C,42, 816-824.

  62. “Odontogenic Differentiation and Dentin Formation of Dental Pulp Cells Under Nanobioactive Glass Induction,” Wang, S., Gao, X., Gong, W., Zhang, Z., Chen, X., & Dong, Y. (2014). Acta Biomaterialia,10(6), 2792-2803.

  63. “Review: Emerging Developments in the Use of Bioactive Glasses for Treating Infected Prosthetic Joints,” Rahaman, M. N., Bal, B. S., & Huang, W. (2014). Materials Science and Engineering: C, 41, 224-231.

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  94. “Using 45S5 Bioglass® Cones as Endosseous Ridge Maintenance Implants to Prevent Alveolar Ridge Resorption: A 5-Year Evaluation,” Harold R. Stanley, Matthew B. Hall, Arthur E. Clark, Caleb J. King III, Larry L. Hench, Joseph J. Berte, J. Oral Maxillofac. Implants, 12 (1997), 95-105.

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  112. “Tissue Response to Surface Active Material”, J. Wilson and L. L. Hench, in The Dental Implant, R.V. McKinney Jr and J.E. Lemons eds., PSG Publishing Co. (1985) 181-196.

  113. “Bioglass Implants for Otology,” L. L. Hench, June Wilson and G. Merwin in Biomaterials in Otology, J. Grote, ed., Martinus Nijhoff Publishers, The Hague-Boston-London, 1983.

  114. “Comparison of Ossicular Replacement Materials in a Mouse Ear Model,” Gerald E. Merwin, James S. Atkins, June Wilson, Larry L. Hench, Head Neck Surg., 90 (1982) 461-469.

  115. “The Implantation of Natural Tooth Form Bioglass® in Baboons – Long Term Results,” H. R. Stanley, L. L. Hench, C. G. Bennett, Jr., S. J. Chellemi, C. J. King, III, R. E. Going, N. J. Ingersoll, E. C. Ethridge, K. L. Kreutziger, L. Loeb, and A. E. Clark, Intern. Oral Implantology 2 (1981) 26-36.

  116. “Toxicology and Biocompatibility of Bioglasses®,” J. Wilson, G. H. Pigott, F. J. Schoen and L. L. Hench, Biomed. Maters. Res. 15 (1981) 805-817.

  117. “Implantation of Natural Tooth Form Bioglasses in Baboon”, H.R. Stanley, J. Oral Implantology, 1:2 (1976)

  118. “The Implantation of Natural Tooth Form Bioglasses in Baboons,” H. R. Stanley, L. L. Hench, R. Going, C. Bennett, S. J. Chellemi, C. King, N. Ingersoll, E. Ethridge, and K. Kreutziger, Oral Surg., Oral Med., Oral Pathology 45[5] (1976) 339-356

  119. “Histo-Chemical Responses at a Biomaterials Interface,” L. L. Hench and H. A. Paschall, Biomed. Mats. Res., No. 5 (Part 1) (1974) 49-64.

  120. “Direct Chemical Bonding of Bioactive Glass-Ceramic Materials and Bone,” L. L. Hench and H. A. Paschall, Biomed. Mats. Res. Symp. No. 4 (1973) 25-42.