Research

 
 

NanoFUSE Biologics are clinically proven to fuse the spine. The synergistic blend of osteoconductive, osteopromotive and anti-infective properties of bioactive glass and osteoinductive property of DBM makes NanoFUSE clinically proven to be more effective than the competition and DBM alone

 
Nano_Fusion_12wks.jpg
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NovaBone_NoFusion_24wks.jpg

Bioactive Glass Research

 

Proven to Heal Bone

Bioactive glass can act as a vehicle for delivering ions beneficial for healing and has been shown to regulate cells and improve bone growth and differentiation. Calcium released from the glass will react with phosphate ions present in the body fluids and deposit a nanocrystalline HA on the glass surface that mimics naturally formed HA by the process in which is made, the size, and morphology of the crystals.

 
 

Proven to Resorb Naturally

The bioactive glass in NanoFUSE is degradable in body fluids. The bioactive glass is chemically soluble, dissolving at rates ranging from ~2 to 5 μm per week.

 
 

Proven to be Anti-Infective

There is a lot of literature on the anti-infective properties of bioactive glass. There are several studies that show successful reduction of infection at the implant site. Bioactive glass is the only
anti-infective synthetic bone grafting material.

 
 

Proven to be Angiogenic

Trace ions in NanoFUSE bioactive glass composition such as copper and zinc are known to stimulate angiogenesis. Bioactive glasses containing these trace elements have been shown to stimulate vascular growth in vivo which can aid in the bone healing process.

 
 

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  110. “Facial Bone Augmentation Using Bioglass® in Dogs”, J. Wilson, G. Merwin,L. Rogers, D.Spilman and R. Martin, in Surgical Research Recent Development, Proc. 1st Annual Scientific Session of Acad. Of Surgical Res., W. Hall, ed. Pergamon Press, (1985), 66-70

  111. Histopathological Evaluation of Interaction between Tympanic Membrane and Implant Materials”, June Wilson, J.S.Atkins, G.E.Merwin and L.L.Hench.Soc. For Biomat. Vol.8 195, 1985

  112. “Tissue Response to Surface Active Material”, J. Wilson and L. L. Hench, in The Dental Implant, R.V. McKinney Jr and J.E. Lemons eds., PSG Publishing Co. (1985) 181-196.

  113. “Bioglass Implants for Otology,” L. L. Hench, June Wilson and G. Merwin in Biomaterials in Otology, J. Grote, ed., Martinus Nijhoff Publishers, The Hague-Boston-London, 1983.

  114. “Comparison of Ossicular Replacement Materials in a Mouse Ear Model,” Gerald E. Merwin, James S. Atkins, June Wilson, Larry L. Hench, Head Neck Surg., 90 (1982) 461-469.

  115. “The Implantation of Natural Tooth Form Bioglass® in Baboons – Long Term Results,” H. R. Stanley, L. L. Hench, C. G. Bennett, Jr., S. J. Chellemi, C. J. King, III, R. E. Going, N. J. Ingersoll, E. C. Ethridge, K. L. Kreutziger, L. Loeb, and A. E. Clark, Intern. Oral Implantology 2 (1981) 26-36.

  116. “Toxicology and Biocompatibility of Bioglasses®,” J. Wilson, G. H. Pigott, F. J. Schoen and L. L. Hench, Biomed. Maters. Res. 15 (1981) 805-817.

  117. “Implantation of Natural Tooth Form Bioglasses in Baboon”, H.R. Stanley et.al., J. Oral Implantology, 1:2 (1976)

  118. “The Implantation of Natural Tooth Form Bioglasses in Baboons,” H. R. Stanley, L. L. Hench, R. Going, C. Bennett, S. J. Chellemi, C. King, N. Ingersoll, E. Ethridge, and K. Kreutziger, Oral Surg., Oral Med., Oral Pathology 45[5] (1976) 339-356

  119. “Histo-Chemical Responses at a Biomaterials Interface,” L. L. Hench and H. A. Paschall, Biomed. Mats. Res., No. 5 (Part 1) (1974) 49-64.

  120. “Direct Chemical Bonding of Bioactive Glass-Ceramic Materials and Bone,” L. L. Hench and H. A. Paschall, Biomed. Mats. Res. Symp. No. 4 (1973) 25-42.